Variations of the perforin gene in patients with chronic inflammatory demyelinating polyradiculoneuropathy
نویسندگان
چکیده
منابع مشابه
Chronic inflammatory demyelinating polyradiculoneuropathy.
The syndrome of acute inflammatory idiopathic polyneuropathy is well known, the predominently motor type of which is recognised by the name of Guillain-Barre Syndrome (GBS), in which the maximum neurological deficit develops rapidly in days, plateaus for weeks and then subsides with the recovery occurring in weeks to months. Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) has e...
متن کاملStance Postural Strategies in Patients with Chronic Inflammatory Demyelinating Polyradiculoneuropathy.
INTRODUCTION Polyneuropathy leads to postural instability and an increased risk of falling. We investigated how impaired motor impairment and proprioceptive input due to neuropathy influences postural strategies. METHODS Platformless bisegmental posturography data were recorded in healthy subjects and patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Each subject...
متن کاملAutonomic dysfunction in chronic inflammatory demyelinating polyradiculoneuropathy.
OBJECTIVES Autonomic deficits in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) have not been adequately quantitated. The Composite Autonomic Severity Score (CASS) is a validated instrument for laboratory quantitation of autonomic failure derived from standard autonomic reflex tests. We characterized dysautonomia in CIDP using CASS. METHODS Autonomic function was retrospecti...
متن کاملPathogenesis of chronic inflammatory demyelinating polyradiculoneuropathy.
Chronic inflammatory demyelinating polyneuropathy (CIDP) is a term applied to a spectrum of immune-mediated demyelinating neuropathies that are heterogeneous in clinical manifestations and probably in pathogenesis. Although histopathologic studies of CIDP have been complicated by a relapsing course of the inflammatory reaction and its predominance in proximal nerve segments, many clues point to...
متن کاملIntravenous Immunoglobulins Lower Inflammatory Gene Expression in Skin Biopsies of Chronic Inflammatory Demyelinating Polyradiculoneuropathy Patients.
according to CIDP Disease Activity Status (CDAS) [4, 6] . Twelve healthy volunteers were used as controls (‘Ctrl’ group). Skin punch biopsies were performed 10 cm above the external malleoli and snap frozen in liquid nitrogen. RNA extraction, gene expression profiling, and MetaCore ® data analysis were performed according to the methods described previously [4] with the following filters: fold ...
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ژورنال
عنوان ژورنال: Genes & Immunity
سال: 2014
ISSN: 1466-4879,1476-5470
DOI: 10.1038/gene.2014.59